CG Life

Media Pitch

Karen Jagoda

Karen Jagoda is the host of the Empowered Patient Podcast, founded in 1998.

Might you be interested in speaking with  Dr. Stacy Lindborg, CEO of IMUNON, a small biotech company in late-stage clinical research developing novel non-viral, DNA-based therapies for cancer and infectious diseases such as COVID-19, for an upcoming podcast episode?

IMUNON has two DNA-based technology platforms: TheraPlas and PlaCCine. They are designed to use DNA as a therapeutic to code for proteins, which our body can then use to produce medicine where needed.

  • TheraPlas is designed to harness interleukin-12 (IL-12), a powerful cytokine and well-validated target for cancer immunotherapy, to teach the body’s immune system to fight cancer at the tumor site.

  • PlaCCine is designed to prompt the body’s immune system to create a vaccine response against infectious diseases such as COVID-19 without needing a virus or device to deliver it.

 

IMUNON recently announced positive Phase 2 data of its IL-12 immunotherapy (IMNN-001) based on TheraPlas technology in advanced ovarian cancer. The company is the first to demonstrate that an IL-12 immunotherapy has the potential to achieve a clinically effective response in ovarian cancer, while alleviating side effects often seen with other immunotherapies. Many IL-12 immunotherapies have failed in the past, so how is IMUNON able to take on the challenge and succeed, while creating a favorable safety profile for patients that has not been seen with other immunotherapies?

Currently, the first two trial sites for Phase 3 Ovation 3 trial have been initiated in May 2025, alomg with study enrollment. Participants will be randomized and include women newly diagnosed with advanced ovarian cancer. With a patient population with limited options, how is IMUNON balancing navigating clinical study coordination as they seek a potential path to commercialization?

Recent Phase 1 data of its DNA-based vaccine (IMNN-101) leveraging PlaCCine technology in treatment of COVID-19 indicate that it may be a viable alternative to mRNA vaccines and able to target the Omicron variant as well as any emerging variants in the future, while offering advantages in terms of manufacturing and storage. How is this technology positioned to better protect against rising pathogens and a potential future outbreak?

Dr. Lindborg can do a deeper dive on these technologies and their unique mechanisms of action, historical challenges in oncology and infectious diseases and unmet needs, and what’s next for the company.

Hope this is of interest!

Thanks,
Rhiju Chakraborty
Account Executive, CG Life
rchakraborty@cglife.com

Harnessing the Immune System Using DNA Therapies: IMUNON CEO Dr. Stacy Lindborg


Hi Karen,